BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B-cell malignancies: a molecular and cytogenetic study
| Autor: | T W, McKeithan, G S, Takimoto, H, Ohno, V S, Bjorling, R, Morgan, B K, Hecht, I, Dubé, A A, Sandberg, J D, Rowley |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Chromosomes Human Pair 14 Gene Rearrangement Male Lymphoma B-Cell Base Sequence Molecular Sequence Data Chromosome Mapping Sequence Analysis DNA Leukemia Lymphocytic Chronic B-Cell Translocation Genetic Electrophoresis Gel Pulsed-Field Blotting Southern B-Cell Lymphoma 3 Protein Karyotyping Proto-Oncogene Proteins Leukemia B-Cell Humans Female Cloning Molecular Chromosomes Human Pair 19 Aged Transcription Factors |
| Zdroj: | Genes, chromosomescancer. 20(1) |
| ISSN: | 1045-2257 |
| Popis: | The t(14;19)(q32.3;q13.1) is a recurring translocation found in the neoplastic cells of some patients with chronic lymphocytic leukemia (CLL) or other B-lymphocytic neoplasms. We previously cloned the translocation breakpoint junctions present in the leukemic cells from three such patients and identified a gene, BCL3, whose transcription is increased as a result of the translocation. In the present paper, we describe three additional patients with the t(14;19), one with lymphoma and two with CLL, and report the cloning and sequencing of the breakpoint junction in one of these patients as well as in a previously reported patient. We and others have found that the breakpoints on chromosome 14, with one exception, fall within the switch region upstream of the immunoglobulin heavy chain C alpha 1 or C alpha 2 sequences. Several of the breaks within chromosome 19 fall immediately upstream of the BCL3 gene, but several others are more than 16 kb 5' of the gene. Most patients with CLL and the t(14;19) also show trisomy 12. |
| Databáze: | OpenAIRE |
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