| Autor: |
Rosendal, Ebba, Wigren, Julia, Groening, Remigius, Yongdae, Kwon, Nilsson, Emma, Sharma, Atin, espaillat, akbar, Hanke, Leo, Thunberg, Therese, McInerney, Gerald, Puhar, Andrea, Cava, Felipe, Karlsson Hedestam, Gunilla B, Monsen, Tor, Elgh, Fredrik, Blomkvist, Bert, Marklund, Ingrid, Ahlm, Clas, Evander, Magnus, Normark, Johan, Johansson, Anders, Overby, Anna K, Forsell, Mattias |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
medRxiv |
| Popis: |
The current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture is usually performed by trained staff at health care centers. Long travel distances may introduce a bias of testing towards relatively large communities with close access to health care centers. Rural regions may thus be overlooked. Here, we demonstrate a sensitive method to measure antibodies to the S-protein of SARS-CoV-2. We adapted and optimized this assay for clinical use together with capillary blood sampling to meet the geographical challenges of serosurveillance. Finally, we tested remote at-home capillary blood sampling together with centralized assessment of S-specific IgG in a rural region of northern Scandinavia that encompasses 55,185 sq kilometers. We conclude that serological assessment from capillary blood sampling gives comparable results as analysis of venous blood. Importantly, at-home sampling enabled citizens living in remote rural areas access to centralized and sensitive laboratory antibody tests. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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