| Autor: |
Valentina Nikolaevna, Blindar, M M, Dobrovolskaya, M N, Khagazheeva, G N, Zubrikhina, Yu A, Nesterova, T V, Davydova, N V, Lyubimova, N E, Kushlinskii, I B, Kononenko, A V, Snegovoy |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Klinicheskaia laboratornaia diagnostika. 66(3) |
| ISSN: |
0869-2084 |
| Popis: |
A study of interleukin-6 (IL-6), hepcidin-25 (GP-25) was conducted in 22 patients with breast cancer before neoadjuvant chemotherapy and in 27 healthy women in the control group. Significant expression of the GP-25 protein was revealed in breast cancer patients, compared to control. The rates were high both in patients with anemic sindrome (AS) and without it (p0.01). Latent iron deficiency, AS, IDA and functional iron deficiency (FJ) were more often detected in patients with stage III disease. A significant difference in the parameters of GP-25 and IL-6 was noted, the indicators were higher in patients with stage III (p0.01). No close correlation was found between IL-6, GP-25 and other acute-phase proteins (FR, CRP) at the initial stages of AS formation. On the contrary, a positive correlation was observed in patients with IDA and FJ between IL-6 and all acute-phase proteins (GP-25, FR, CRP). However, a small number of observations do not allow an unambiguous conclusion about the role of IL-6 and GP-25 expression in the development of AS in cancer patients with breast cancer and requires further study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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