| Autor: |
Xiao, Jiang, Xiao-Xiong, Wang, Hao, Lu, Shi-Rong, Chen, Ding-Qiong, Xiao, Meng, Zhao, Xiu-Li, Li, Ge, Zhang, Guo-Hui, Xu, Zhu-Zhong, Cheng |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 48(2) |
| ISSN: |
1672-173X |
| Popis: |
To synthesize 3'-deoxy-3'-¹⁸F-fluorotyhymidine)(¹⁸F-FLT) using CFN-MPS-200 automatic synthesis module, and evaluate its distribution in Wistar rats.We used 3-N-Boc-5!d-O-dimethoxytrityl-3!d-O-nosyl-thymidine (Boc-FLT)-percursor as raw material to synthesize ¹⁸F-FLT without residual solvents. Its radiochemical purity was confirmed with radio-HPLC and thin layer chromatography (TLC). Normal Wistar rats were injected withThe entire preparation procedure took about 60 min, which resulted in a radio chemical yield of (24±5)% (after attenuation correction,Automated synthesis of ¹⁸F-FLT using CFN-MPS-200 is a stable method, with high yield, safety without solvent, and acceptable quality. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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