| Autor: |
W H, Sutherland, N J, Lewis-Barned, M C, Pratt, H C, Tillman, R J, Walker |
| Rok vydání: |
1994 |
| Předmět: |
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| Zdroj: |
Research communications in chemical pathology and pharmacology. 83(1) |
| ISSN: |
0034-5164 |
| Popis: |
The effect of acute hyperinsulinemia on plasma lipoprotein a [Lp(a)] concentration in 25 patients with non-insulin dependent diabetes mellitus (NIDDM) and in 10 healthy subjects was examined. Insulin was infused into the subjects for 2 hours while baseline plasma glucose concentrations were maintained. Plasma Lp(a) levels showed a small but significant mean (+/- SD) increase in NIDDM patients (12 +/- 26 U/l, p0.01) but did not vary significantly in healthy subjects (3 +/- 15 U/l) when insulin was infused. There was considerable individual variation (-35 to 98 U/l) in the response of Lp(a) to acute hyperinsulinemia and the response was correlated significantly with baseline Lp(a) levels (r = 0.399, p0.05). These data suggest that acute hyperinsulinemia at constant baseline glucose levels may raise plasma Lp(a) levels in NIDDM patients more particularly in those with high initial Lp(a) concentrations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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