A method for fast multislice T1 measurement: feasibility studies on phantoms, young children, and children with Canavan's disease

Autor:	J, Haselgrove, J, Moore, Z, Wang, E, Traipe, L, Bilaniuk
Rok vydání:	2000
Předmět:	Canavan Disease Phantoms Imaging Brain Infant Reproducibility of Results Magnetic Resonance Imaging Nerve Fibers Myelinated Nonlinear Dynamics Child Preschool Linear Models Feasibility Studies Humans Regression Analysis Computer Simulation Algorithms
Zdroj:	Journal of magnetic resonance imaging : JMRI. 11(4)
ISSN:	1053-1807
Popis:	We have developed a multislice protocol for quantitative T1 measurements in which the processing time and the acquisition time are under 2 minutes each for a complete brain study of 15 slices. An echoplanar, inversion-recovery image sequence is designed to collect data suitable for analysis using a linear regression algorithm. The precision is approximately twice the noise to signal ratio of the images. The accuracy of the protocol is better than 1% for T1 in the range 0-2 seconds and deviates slightly for longer T1 values. The protocol is insensitive to B1 field values. If needed, the data can be postprocessed using a slow, nonlinear algorithm to give an accuracy of less than 1% and a precision of approximately the noise to signal ratio throughout a range of T1 values from 0 to 4 seconds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::19608875338d515e08964de2196a0f45 https://pubmed.ncbi.nlm.nih.gov/10767064 Zobrazit plný text záznamu Plný text