| Autor: |
J, Mackenney, M J, Oyarzun, P V, Diaz, R, Bustos, H, Amigo, R J, Rona |
| Rok vydání: |
2005 |
| Předmět: |
|
| Zdroj: |
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. 9(11) |
| ISSN: |
1027-3719 |
| Popis: |
To assess the prevalence of asthma symptoms and their association with sensitisation to eight allergens and bronchial hyperresponsiveness (BHR) to methacholine.A random sample of 1232 adults, aged 22 to 28 years, studied in a Chilean semi-rural area.A cross-sectional design for the purpose of this analysis.The prevalence of wheeze was 27.4% (95%CI 24.9-29.9) and waking with breathlessness 13.7% (95%CI 11.8-15.6), higher than the results of a multi-centre European study. Only 7.8% (95%CI 6.3-9.3) had a positive BHR (or =8 mg/ml) and 26.3% (95%CI 23.8-28.8) were atopic. The Youden index of asthma symptoms in non-atopic subjects varied from 0.184 to 0.259 when using BHR as gold standard for asthma, and increased from 0.379 to 0.504 among those with positive atopy. Only 4.5% reported asthma, and the Youden index was slightly higher in comparison to the asthma symptom groups.The prevalence of asthma symptoms in young adults was high, but only a small proportion of these were sensitised or had a positive BHR. We believe that aetiological studies of asthma should analyse subjects with asthma symptoms separately from those with positive atopic status or positive BHR. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
