| Autor: |
Masanori, Murakoshi, Rie, Ikeda, Norio, Fukui, Masashi, Tagawa |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
The Tokai journal of experimental and clinical medicine. 27(4) |
| ISSN: |
0385-0005 |
| Popis: |
In order to confirm the relationship between glutathione-peroxidase (GSH-PO) and testosterone action in rat ventral prostate, we have studied the immunocytochemical localization of GSH-PO in glandular epithelial cells of rat ventral prostate after chlormadinone acetate CMA) as antiandrogen. In the control rat ventral prostate, GSH-PO was predominantly observed in the glandular epithelial cells and intracellular localization of GSH-PO was exclusively observed in the cytoplasmic matrix near the rough endoplasmic reticulum and it was occasionally noted as small granular structure. In CMA-administered rats, the glandular epithelial cells of the ventral prostate were markedly atrophic. The intensity of GSH-PO staining in the glandular epithelial cells was markedly decreased. Immunoelectron microscopically, GSH-PO-positive granules were hardly seen in the atrophic glandular epithelial cells. These findings strongly suggest that loss of GSH-PO staining in the glandular epithelial cells of the rat ventral prostate treated with CMA a s antiandrogen is thought to be caused by inhibition of testosterone action, and that its staining pattern is useful for the effect of antiandrogens or antiprostatic agents on prostate. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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