Hemodynamic Optimization in Cardiac Resynchronization Therapy: Should We Aim for dP/dt

Autor: Alwin, Zweerink, Odette A E, Salden, Wouter M, van Everdingen, Gerben J, de Roest, Peter M, van de Ven, Maarten J, Cramer, Pieter A, Doevendans, Albert C, van Rossum, Kevin, Vernooy, Frits W, Prinzen, Mathias, Meine, Cornelis P, Allaart
Rok vydání: 2018
Předmět:
Zdroj: JACC. Clinical electrophysiology. 5(9)
ISSN: 2405-5018
Popis: This study evaluated the acute effect of dP/dtHemodynamic optimization may increase benefit from CRT. Typically, maximal left ventricular (LV) pressure rise dP/dtForty-one patients underwent CRT implantation followed by invasive PV loop measurements. The stimulation protocol included 16 LV pacing configurations using each individual electrode of the quadripolar lead with 4 atrioventricular (AV) delays. Conventional CRT was defined as pacing from the distal electrode with an AV delay of approximately 120 ms.Compared with conventional CRT, dP/dtPV-guided hemodynamic optimization in CRT results in approximately one-third SW improvement on top of conventional CRT, caused by a mechanism of enhanced VA coupling. In contrast, dP/dt
Databáze: OpenAIRE