[Investigation of antiviral activity of adamantan boron derivaties on pandemic influenza virus models]

Autor: S G, Markushin, N A, Kantarov, S V, Artiushenko, I I, Akopova, I B, Koptiaeva, Iu N, Bubnov
Rok vydání: 2011
Předmět:
Zdroj: Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic]. 56(5-6)
ISSN: 0235-2990
Popis: Comparative investigation of the virus-inhibiting activity of some boron-containing compounds showed that products BG 12 and BG 4 had the highest inhibitory effect on pandemic viruses. The minimum inhibitory concentration (MIC) of the products was 0.1 mcg/ml. The use of liposomes loaded with BG 12 molecules in the optimal concentration (0.1 mcg/ml) resulted in inhibition of the avian plague virus growth in the MDCK cells. Possible design of efficient drugs for antiviral protection based on the complexes liposomes--boron-containing compounds is discussed.
Databáze: OpenAIRE