The Role of Fluconazole Prophylaxis Regimen and the Regimes Chosen by the Patient’s Risk of Fungal Infection in Reducing the Infection Rate after Bone Marrow Transplantation
| Autor: | Pourghasemian, Mehdi, Mehdizadeh, Mahshid, Hajfathali, Abbas, Habibzadeh, Afshin, Hosseini, Mohammad Hossein |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Antifungal Agents Bone marrow transplantation Adolescent fungal infection Middle Aged Young Adult Cross-Sectional Studies Treatment Outcome Risk Factors Humans Female Pre-Exposure Prophylaxis prophylaxis Chemical and Drug Induced Liver Injury Child Fluconazole Invasive Fungal Infections Research Article Aged Follow-Up Studies Retrospective Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention : APJCP |
| ISSN: | 2476-762X 1513-7368 |
| Popis: | Objective: Invasive fungal infections (IFI) in bone marrow transplant (BMT) recipients are common and lethal. Fluconazole was the choice prophylaxis previously, but recent strategy utilization antifungal drugs according to the risk of IFI in patients undergoing transplantation. In this study we aim to evaluate the efficacy of fluconazole prophylaxis regimen and the regimes chosen by the patient’s risk of IFI. Materials and Methods: We evaluated 376 patients with BMT. Patients were divided into those treated before 2012 with fluconazole prophylaxis (group I, n=206) or those undergone transplantation after 2012 and received fluconazole, voriconazole and posaconazole prophylaxis according their risk of fungal infection (group II, n=170). Results: Group I was significantly younger (p=0.007), less smoker (p=0.01), received more autologus transplant (p=0.001) and mostly high risk patient for infection (p |
| Databáze: | OpenAIRE |
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