| Autor: |
Meng-Yuan, Li, Zhong-Qiang, Yao, Xiang-Yuan, Liu |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Sheng li ke xue jin zhan [Progress in physiology]. 42(1) |
| ISSN: |
0559-7765 |
| Popis: |
Ankylosing spondylitis (AS) is an autoimmune disease which has a strong association with HLA-B27. Its pathogenesis includes the interaction between microorganism and host, the recognition of MHC class I molecule by immune cells and the imbalance of the cytokine network and so on. Unfolded protein response (UPR) participates in the development of AS. And the activation of the IL-23/IL-17 axis, which is in the downstream of UPR, may make a critical contribution to the pathogenesis. UPR and IL-23/IL-17 axis open new avenues of investigation as well as identifying new therapeutic target in this disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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