Synthesis and biological evaluation of modified laminin peptide (N

Autor:	Raunak, Varshney, Puja P, Hazari, Anjani K, Tiwari, Rashi, Mathur, Aruna, Kaushik, Meenakshi, Saklani, Sweta, Singh, Ankur, Kaul, Roger, Stromberg, Anil K, Mishra
Rok vydání:	2020
Předmět:	Neurons Galectins Neuronal Outgrowth Brain Mice Nude Blood Proteins Molecular Imaging Molecular Docking Simulation Cell Line Tumor Animals Humans Laminin Rabbits Radiopharmaceuticals Protein Binding
Zdroj:	Bioorganic chemistry. 107
ISSN:	1090-2120
Popis:	An analog of γ1 laminin (RDIAEIIKDI) decapeptide has been used to augment neuronal survival and regeneration after injuries, during aging and other CNS disorder. As a prime synthetic peptide, KDI, is responsible for the neurite outgrowth of human embryonic neurons. In this study, we have designed, modified a KDI derivative and synthesized by replacing isoleucine (I) with Pro (P) amino acid at C-terminal to enhance its potency towards neurite growth. -Cys-Gly-Cys (-CGC) N
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::1881fe1979212f1b69d9f8074b7dc07b https://pubmed.ncbi.nlm.nih.gov/33293057 Zobrazit plný text záznamu Full Text from ScienceDirect