| Autor: |
A, Prelle, M, Sciacco, G P, Comi, S, Messina, M, Carpo, P, Ciscato, E, Nobile Orazio, F, Fortunato, G, Mora, V, Bignotti, G, Fagiolari, M, Moggio, G, Scarlato |
| Rok vydání: |
2000 |
| Předmět: |
|
| Zdroj: |
Clinical neuropathology. 19(4) |
| ISSN: |
0722-5091 |
| Popis: |
Recently, abnormal expression of cyclin-dependent kinases was proposed as a possible cause of desminopathy. We describe an atypical case clinically characterized by severe respiratory distress. Muscle biopsy showed subsarcolemmal and intracytoplasmic accumulation areas, which intensively stained with anti-desmin antibodies and contained electrondense filamentous material at ultrastructural level. WB analysis showed 30% increased desmin signal compared to controls. Positive immunostain for CDC2 kinase, CDK2 and emerin and nuclear matrix-associated protein were, found in desmin-positive fibres. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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