| Autor: |
M, Muñoz-Torres, P, Mezquita-Raya, F, Lopez-Rodriguez, E, Torres-Vela, J, de Dios Luna, F, Escobar-Jimenez |
| Rok vydání: |
2002 |
| Předmět: |
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| Zdroj: |
Clinical endocrinology. 55(6) |
| ISSN: |
0300-0664 |
| Popis: |
The pathogenic role of the decline in serum concentrations of IGF-I in postmenopausal osteoporosis is not fully elucidated. We investigated the associations among IGF-I, bone mineral density (BMD), ultrasound parameters and prevalence of vertebral fractures in postmenopausal women.A cross-sectional study.One hundred and fifty-four ambulatory postmenopausal women (61 +/- 7 years) referred for osteoporosis screening.IGF-I was measured by radioimmunoassay and BMD using dual-energy X-ray absorptiometry. Broadband ultrasound attenuation (BUA) and speed of sound (SOS) at calcaneus were measured by a quantitative ultrasound system.IGF-I was significantly lower in osteoporotic subjects and correlated positively with BMD, BUA and SOS. After adjusting for age, years since menopause and body mass index, IGF-I accounted for 8.5% of the variance at lumbar spine BMD, 4.6% at femoral neck and 7.1% at calcaneal BUA. BUA was associated with IGF-I independently of BMD. IGF-I was lower in women with vertebral fractures (91 +/- 39 microg/l vs. 114 +/- 44 microg/l; P = 0.003). The osteoporosis densitometric criteria (t-scoreor = -2.5 SD) was the most strongly independent associated variable with prevalent vertebral fractures [odds ratio (OR): 3.3 (1.4-7.6)], followed by IGF-I levels below 75th percentile [OR: 3 (1-8.8)].Our study shows that IGF-I is strongly associated with bone mineral density and reflects aspects of bone quality. The contribution of IGF-I to skeletal integrity in postmenopausal women is clinically relevant. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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