| Autor: |
A V D, Melo Bisneto, L C D, Oliveira, A, Silva Fernandes, L S, Silva, J H, Véras, C G, Cardoso, Carolina R, E Silva, A V, de Moraes Filho, C C, Carneiro, L, Chen-Chen |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of toxicology and environmental health. Part A. 84(6) |
| ISSN: |
1528-7394 |
| Popis: |
Azathioprine (Aza) is a purine antimetabolite immunosuppressant that is widely employed for immunosuppressive therapy in post-transplant recipients or patients with autoimmune diseases. Chronic use of immunosuppressants might produce several side effects, including a high rate of neoplasms in these patients. Considering that genotoxic effects are associated with an increased risk of developing cancer, the aim of this study was to examine the recombinogenic, genotoxic, and cytotoxic effects of Aza using Somatic Mutation and Recombination Test (SMART) in |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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