Role of soy diet and L-arginine in cyclosporin-A-induced osteopenia in rats

Autor:	G, Clementi, C E, Fiore, N G, Mangano, V M, Cutuli, P, Pennisi, A, Caruso, A, Prato, M, Matera, M, Amico-Roxas
Rok vydání:	2001
Předmět:	Male Body Weight Arginine Spine Diet Rats Radiography Rats Sprague-Dawley Bone Diseases Metabolic Disease Models Animal Bone Density Cyclosporine Soybean Proteins Animals Calcium Drug Therapy Combination Pelvic Bones Immunosuppressive Agents Injections Intraperitoneal
Zdroj:	Pharmacologytoxicology. 88(1)
ISSN:	0901-9928
Popis:	Our previous studies show that chronic administration of L-arginine decreases cyclosporin-A-induced bone loss. The present study was designed to investigate whether a soy diet could prevent cyclosporin A-induced osteopenia and eventually improve the protective effect of L-arginine. Rats on soy diet were treated with cyclosporin-A, L-arginine, cyclosporin-A + L-arginine or saline. Control groups received a normal diet and the same pharmacological treatment. Our results show that a soy diet prevents osteopenia only in the spinal cord (+30%) and confirm the protective effect of L-arginine in cyclosporin-A-induced osteopenia in whole body, pelvis and spine of rats on a normal diet (+31%, +55%, +55%, respectively). Moreover these data show that the osteoprotective effect of L-arginine in the whole body, pelvis and spine improves in the case of soy diet (+60%, +72%, +89%, respectively). The results suggest that a soy diet exerts a positive effect in cyclosporin-A-induced osteopenia only in sites with high turn-over and improves the osteoprotective effect of L-arginine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::181b7a3d6d19e46eddf1e7bd02279da9 https://pubmed.ncbi.nlm.nih.gov/11169156 Zobrazit plný text záznamu Plný text