High-pressure liquid chromatographic analysis of drugs in biological fluids. IV. Determination of clofibrinic acid

Autor: T D, Bjornsson, T F, Blaschke, P J, Meffin
Rok vydání: 1977
Předmět:
Zdroj: Journal of chromatography. 137(1)
Popis: A rapid, sensitive and specific high-pressure liquid chromatographic method is described for the quantitative analysis of clofibrinic acid in plasma, saliva and urine. In contrast to previously reported gas-liquid chromatographic methods, which require derivatization of clofibrinic acid before chromatography, the present method involves a simple two-step extraction procedure and chromatographic determination of the underivatized clofibrinic acid. Concentrations between 1.0 and 25.0 microgram per sample can be measured with a coefficient of variation from 1 to 6%.
Databáze: OpenAIRE