Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer
| Autor: | R, Parsons, L L, Myeroff, B, Liu, J K, Willson, S D, Markowitz, K W, Kinzler, B, Vogelstein |
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| Rok vydání: | 1995 |
| Předmět: |
Base Sequence
Molecular Sequence Data Receptor Transforming Growth Factor-beta Type II Mice Nude DNA Neoplasm Sequence Analysis DNA DNA Satellite Protein Serine-Threonine Kinases Colorectal Neoplasms Hereditary Nonpolyposis Polymerase Chain Reaction Mice Mutation Tumor Cells Cultured Animals Humans Receptors Transforming Growth Factor beta |
| Zdroj: | Cancer research. 55(23) |
| ISSN: | 0008-5472 |
| Popis: | The TGF beta type II receptor (RII) was found to be mutated within a polyadenine tract in 100 of 111 (90%) colorectal cancers with microsatellite instability. Other polyadenine tracts of similar length were mutated in these samples but not as frequently as RII. In most cases, the polyadenine tract mutations affected both alleles of RII, and in four tumors heterozygous for the polyadenine mutations, three had additional mutations that were expected to inactivate the other RII allele. These genetic data support the idea that RII behaves like a tumor suppressor during CR cancer development and is a critical target of inactivation in mismatch repair-deficient tumors. |
| Databáze: | OpenAIRE |
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