| Autor: |
Michele, Navarra, Angelo Pietro, Femia, Andrea, Romagnoli, Katia, Tortora, Cristina, Luceri, Santa, Cirmi, Nadia, Ferlazzo, Giovanna, Caderni |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
European journal of nutrition. 59(3) |
| ISSN: |
1436-6215 |
| Popis: |
To determine the potential of a flavonoid-rich extract from bergamot juice (BJe) to prevent colorectal carcinogenesis (CRC) in vivo.Pirc rats (F344/NTac-ApcRats treated with BJe showed a significant dose-related reduction in the colon preneoplastic lesions mucin-depleted foci (MDF). Colon and small intestinal tumours were also significantly reduced in rats supplemented with 70 mg/kg of BJe. To elucidate the involved mechanisms, markers of inflammation and apoptosis were determined. Compared to controls, colon tumours from BJe 70 mg/kg-supplemented rats showed a significant down-regulation of inflammation-related genes (COX-2, iNOS, IL-1β, IL-6 and IL-10 and Arginase 1). Moreover, in colon tumours from rats fed with 70 mg/kg BJe, apoptosis was significantly higher than in controls. Up-regulation of p53 and down-regulation of survivin and p21 genes was also observed.These data indicate a strong chemopreventive activity of BJe that, at least in part, is due to its pro-apoptotic and anti-inflammatory actions. This effect could be exploited as a strategy to prevent CRC in high-risk patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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