| Autor: |
Tian-Tian, Gan, Qi, Liao, Ji-Hui, Wang, Zhi-Heng, Fan, Jian, Cao, Hui-Ju, Pan, Gao-Feng, Lou, Xue-Fen, Dong, Wei, Ouyang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Sheng li xue bao : [Acta physiologica Sinica]. 74(3) |
| ISSN: |
0371-0874 |
| Popis: |
The mechanisms underlying exercise-induced neuroprotective effects after traumatic brain injury (TBI) remained elusive, and there is a lack of effective treatments for TBI. In this study, we investigated the effects of an integrative approach of exercise and Yisaipu (TNFR-IgG fusion protein, TNF inhibitor) in a mouse TBI model. Male C57BL/6J mice were randomly assigned to a sedentary group or a group that followed a voluntary exercise regimen. The effects of 6-week prophylactic preconditioning exercise (PE) alone or in combination with post-TBI Yisaipu treatment on moderate TBI associated deficits were examined. The results showed that combined treatments of PE and post-TBI Yisaipu were superior to single treatments on reducing sensorimotor and gait dysfunctions in mice. These functional improvements were accompanied by reduced systemic inflammation largely via decreased serum TNF-α, boosted autophagic flux, and mitigated lesion volume after TBI. Given these neuroprotective effects, composite approaches such as a combination of exercise and TNF inhibitor may be a promising strategy for facilitating functional recovery from TBI and are worth further investigation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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