Neuroprotective effects of riluzole on N-methyl-D-aspartate- or veratridine-induced neurotoxicity in rat hippocampal slices

Autor:	C, Malgouris, M, Daniel, A, Doble
Rok vydání:	1994
Předmět:	Male Veratridine N-Methylaspartate Riluzole Cell Death L-Lactate Dehydrogenase Nerve Tissue Proteins Hippocampus Receptors N-Methyl-D-Aspartate Sodium Channels Rats Rats Sprague-Dawley Thiazoles Pertussis Toxin Animals Female Virulence Factors Bordetella
Zdroj:	Neuroscience letters. 177(1-2)
ISSN:	0304-3940
Popis:	The neuroprotective activity of riluzole has been studied on N-methyl-D-aspartate (NMDA)- or veratridine-induced toxicity in immature rat hippocampal slices. Neurodegeneration was assessed by the measurement of LDH release and histology. Veratridine-induced LDH release can be inhibited by 100 microM riluzole (-90% and by tetrodotoxin (1 microM). Riluzole markedly reduced (-59%) the NMDA-induced LDH release and this protective effect was confirmed by histology. Riluzole inhibited the NMDA-induced LDH release in the presence of tetrodotoxin. Moreover, a pretreatment with pertussis toxin (1 microgram/ml) abolished the effect of riluzole against NMDA-induced neurotoxicity. These results support the view that the neuroprotective properties of riluzole could be exerted via two distinct mechanisms of action.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::17f5f5937466b8820db3c9a25df24355 https://pubmed.ncbi.nlm.nih.gov/7824190 Zobrazit plný text záznamu