A comparison of nicotine content methods to produce a UPC

Autor:	Randi R, Carter, Alexander L, Kovach, Brian F, Thomas
Rok vydání:	2022
Předmět:	Nicotine Alkaloids Tobacco Tobacco Products Gas Chromatography-Mass Spectrometry
Zdroj:	Analytical and bioanalytical chemistry. 414(19)
ISSN:	1618-2650
Popis:	Nicotine is the principal alkaloid in tobacco and has been the primary subject of scientific investigation for its pharmacological effects contributing to tobacco use, dependence, withdrawal, and physical harm. Related minor alkaloids, accounting for less than 6% of alkaloid content in tobacco leaves, may also mirror some of the same pharmacological effects. To detect such low concentrations of the minor alkaloids, tobacco product methods produced by the Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) using gas chromatography and flame ionization detection (GC-FID) have been adapted for use with gas chromatography-mass spectrometry (GC-MS). Nicotine and minor alkaloid content in SPECTRUM Nicotine Research Cigarettes (NRC) have previously been determined using GC-FID; however, the minor alkaloids were unable to be detected or quantitated. This study employed UltraPerformance Convergence Chromatography (UPC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::17e1a8e1b27f98989ab96f75a2668a37 https://pubmed.ncbi.nlm.nih.gov/35676561 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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