| Autor: |
L J, Lee, X, Sha, M H, Gotfried, J R, Howard, R K, Dix, D N, Fish |
| Rok vydání: |
1998 |
| Předmět: |
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| Zdroj: |
Pharmacotherapy. 18(1) |
| ISSN: |
0277-0008 |
| Popis: |
To evaluate the pulmonary tissue distribution of levofloxacin, the new once-daily fluoroquinolone, after a single 500-mg oral dose.Open-label study.One pulmonary clinic and two university-affiliated teaching hospitals.Eighteen adults undergoing lung biopsy or lobectomy.Levofloxacin plasma and lung tissue concentrations were determined by high-performance liquid chromatography with fluorescence detection. Lung tissue levofloxacin concentrations were corrected for blood contamination by measuring hemoglobin.After a single 500-mg oral dose, concentrations of levofloxacin in lung tissue consistently exceeded those in plasma at every time point over the 24-hour sampling period, with tissue:plasma penetration ratios of 2.02 (2-3 hrs), 5.02 (4-6 hrs), 5.13 (11-17 hrs), and 4.13 (22-25 hrs). The mean penetration ratio over the 24-hour sampling period was 3.95 (range 1.06-9.98). Lung tissue concentrations of levofloxacin also exceeded minimum inhibitory concentration values for most community-acquired respiratory tract pathogens over the 24 hours.This study supports clinical evaluation of levofloxacin as once-daily oral therapy for community-acquired lower respiratory tract infections. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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