| Autor: |
B A, Perret, M, Senn, P, Affentranger, M, Poorbeik, J J, Burckhardt, A, Morell |
| Jazyk: |
němčina |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Schweizerische medizinische Wochenschrift. 123(3) |
| ISSN: |
0036-7672 |
| Popis: |
The sera of patients with hemophilia and von Willebrand factor deficiency, collected during clinical trials with virus-inactivated coagulation factor preparations, were retrospectively screened for the presence of antibodies against hepatitis C virus (HCV). Using the anti-HCV c100-3 assay, 10 out of 35 study patients had no HCV antibodies when entering the studies. The samples originally negative for anti-HCV were retested with a second-generation assay: all negative samples except two were positive on retesting. We conclude that the HCV seroprevalence in Swiss hemophiliacs must be of the order of90%. These results confirm that the first-generation assay for HCV antibodies is not sensitive enough; to obtain more accurate information on the seroprevalence of hemophiliacs, second-generation tests should be used. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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