| Autor: |
Seyed Mostafa, Goldansaz, Carmen, Festa, Ester, Pagano, Simona, De Marino, Claudia, Finamore, Olga Alessandra, Parisi, Francesca, Borrelli, Ali, Sonboli, Maria Valeria, D'Auria |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Molecules |
| ISSN: |
1420-3049 |
| Popis: |
The n-butanolic extract, from an Iranian specimen of Nepeta asterotricha Rech. f. (NABE), displayed anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated J774A.1 macrophages, which reduced nitrites and cytokines production. Bioassay guided fractionation of the extract led to the isolation of four iridoid glycosides, including a new one known as nepetamoside (1), one hexenyl-diglycoside, and some polyphenol and flavonoid components. None of the isolated iridoid components displayed significant effects on nitrites formation in an in vitro LPS-induced model of inflammation, thus suggesting that the plant anti-inflammatory effect is probably due to a synergistic action among its constituents. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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