| Autor: |
Elisa M T, Melloni, Beatrice, Bravi, Sara, Poletti, Sara, Dallaspezia, Barbara, Barbini, Raffaella, Zanardi, Francesco, Benedetti |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Progress in neuro-psychopharmacologybiological psychiatry. 119 |
| ISSN: |
1878-4216 |
| Popis: |
Dysfunctional glutamatergic neurotransmission has been proposed both, as a biological underpinning of mood disorder and as a target for rapid-acting antidepressant treatments. Total sleep deprivation and light therapy (TSD + LT) can prompt antidepressant response in drug-resistant bipolar depression. Here we explored the effects of TSD + LT on dorsolateral prefrontal cortex (DLPFC) glutamate and/or glutamine+glutamate (Glx) levels.We studied single voxelHigher concentration of Glu (adjusted Z = -2189, p = 0,0285) and Glx (adjusted Z = -3,13, p = 0,0017) were observed in BD patients compared to HC. Treatment caused a significant rapid reduction of depressive symptom severity over time (F = 63.98, p 0.01). Change in depression levels after TSD + LT treatment was significantly influenced by delta change in Glu levels (LR χA reduction in Glu and Glx levels associated with depression could contribute to the mechanism of action of TSD + LT, directly acting on glutamatergic neurons, or to the interaction between the glutamatergic system and dopamine (DA) and serotonin (5-HT) levels, known to be targeted by TSD. This is in line with several studies showing a glutamatergic modulation effects of antidepressants and mood stabilizing agents. This finding deepens our understanding of antidepressant effect of chronoterapeutics. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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