| Autor: |
E V, Bouzinova, L, Hangaard, C, Staehr, A, Mazur, A, Ferreira, A V, Chibalin, S L, Sandow, Z, Xie, C, Aalkjaer, V V, Matchkov |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Acta physiologica (Oxford, England). 224(1) |
| ISSN: |
1748-1716 |
| Popis: |
The Na,K-ATPase is involved in a large number of regulatory activities including cSrc-dependent signalling. Upon inhibition of the Na,K-ATPase with ouabain, cSrc activation is shown to occur in many cell types. This study tests the hypothesis that acute potentiation of agonist-induced contraction by ouabain is mediated through Na,K-ATPase-cSrc signalling-dependent sensitization of vascular smooth muscle cells to CaAgonist-induced rat mesenteric small artery contraction was examined in vitro under isometric conditions and in vivo in anaesthetized rats. Arterial wall tension and [CaTen micromolar ouabain, but not digoxin, potentiated contraction to noradrenaline. This effect was not endothelium-dependent. Ouabain sensitized smooth muscle cells to CaData suggest that micromolar ouabain potentiates agonist-induced contraction of rat mesenteric small artery via Na,K-ATPase-dependent cSrc activation, which increases Ca |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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