Prior Exercise Training Prevent Hyperglycemia in STZ Mice by Increasing Hepatic Glycogen and Mitochondrial Function on Skeletal Muscle

Autor:	Afonso Kopczynski, de Carvalho, Sabrina, da Silva, Edenir, Serafini, Daniela Roxo, de Souza, Hemelin Resende, Farias, Gustavo, de Bem Silveira, Paulo Cesar Lock, Silveira, Claudio Teodoro, de Souza, Luis Valmor, Portela, Alexandre Pastoris, Muller
Rok vydání:	2016
Předmět:	Mice Oxygen Consumption Hyperglycemia Physical Conditioning Animal Animals Muscle Skeletal Oxidation-Reduction Diabetes Mellitus Experimental Liver Glycogen Mitochondria Muscle
Zdroj:	Journal of cellular biochemistry. 118(4)
ISSN:	1097-4644
Popis:	Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. We investigated the effect of a prior 30 days voluntary exercise protocol on STZ-diabetic CF1 mice. Glycemia, and the liver and skeletal muscle glycogen, mitochondrial function, and redox status were analyzed up to 5 days after STZ injection. Animals were engaged in the following groups: Sedentary vehicle (Sed Veh), Sedentary STZ (Sed STZ), Exercise Vehicle (Ex Veh), and Exercise STZ (Ex STZ). Exercise prevented fasting hyperglycemia in the Ex STZ group. In the liver, there was decreased on glycogen level in Sed STZ group but not in EX STZ group. STZ groups showed decreased mitochondrial oxygen consumption compared to vehicle groups, whereas mitochondrial H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::17598f9e6426b9b4936dc8787a8d45bb https://pubmed.ncbi.nlm.nih.gov/27447720 Zobrazit plný text záznamu Plný text