| Autor: |
Cao, Tianle, Ma, Sen, Wang, Nan, Gharabaghi, Sara, Xie, Yibin, Fan, Zhaoyang, Hogg, Elliot, Wu, Chaowei, Han, Fei, Tagliati, Michele, Haacke, E. Mark, Christodoulou, Anthony G., Li, Debiao |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Magn Reson Med |
| Popis: |
PURPOSE: To develop a new technique that enables simultaneous quantification of whole brain T1, T2, T2*, as well as susceptibility and synthesis of six contrast-weighted images in a single 9.1min scan. METHODS: The technique employs hybrid T2-prepared inversion recovery (T2-IR) pulse modules and multi-echo gradient echo (GRE) readouts to collect k-space data with various T1, T2 and T2* weightings. The underlying image is represented as a six-dimensional low-rank tensor consisting of three spatial dimensions and three temporal dimensions corresponding to T1 recovery, T2 decay, and multi-echo behaviors respectively. Multiparametric maps were fitted from reconstructed image series. The proposed method was validated on phantoms and healthy volunteers, by comparing quantitative measurements against corresponding reference methods. The feasibility of generating six contrast-weighted images was also examined. RESULTS: High quality, co-registered T1/T2/T2*/susceptibility maps were generated that closely resembled the reference maps. Phantom measurements showed substantial consistency (R(2)>0.98) with the reference measurements. Despite the significant differences of T1 (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
