| Autor: |
Elena D, Dimitrakova, Jordan D, Dimitrakov, S A, Karumanchi, S G, Karumanchi, Blagovest K, Pehlivanov, Nikola P, Milchev, Dimitar I, Dimitrakov |
| Rok vydání: |
2004 |
| Předmět: |
|
| Zdroj: |
Folia medica. 46(1) |
| ISSN: |
0204-8043 |
| Popis: |
The pathophysiology of preeclampsia remains largely unknown. A number of circulating placenta-produced factors have been implicated in causing the endothelial dysfunction and the clinical phenotype characteristic of preeclampsia.Determination of serum levels of placental soluble fms-like tyrosine-kinase-1 (sFlt-1) in pregnant women with preeclampsia. Eleven pregnant women with preeclampsia and 11 healthy women (controls) were included in the study. Determination of sFlt-1 was done with ELISA. The mean serum sFlt-1 levels of pregnant women with preeclampsia were twice as high as that of women with normal pregnancy. The highest level of sFlt-1 was found in women with severe preeclampsia. In women with mild form of preeclampsia the sFlt-1 level was close to that of the controls. sFlt-1 appears to be involved in the pathogenesis of preeclampsia and its serum levels can be used as a diagnostic marker of preeclampsia. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
