[Contribution of an induction treatment in the surgical treatment of locally advanced non-small-cell cancers]
| Autor: | G, Massard, B, Sohier, G M, Jung, A, Dietemann, R, Kessler, P, Dumont, P, Fraisse, A, Charloux, C, Bohner, J M, Wihlm |
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| Jazyk: | francouzština |
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Antimetabolites Antineoplastic Lung Neoplasms Antineoplastic Agents Radiotherapy Dosage Middle Aged Combined Modality Therapy Postoperative Complications Carcinoma Non-Small-Cell Lung Antineoplastic Combined Chemotherapy Protocols Preoperative Care Humans Female Fluorouracil Cisplatin Aged Follow-Up Studies |
| Zdroj: | Annales de chirurgie. 49(9) |
| ISSN: | 0003-3944 |
| Popis: | From October 1988 to July 1990, 18 patients with marginally resectable non-small cell cancer (10 stage IIIa and 8 stage IIIb) were entered in a phase-II trial combining induction therapy with a subsequent thoracotomy. Induction therapy included 2 courses of chemotherapy (5-FU and cisplatinum) and radiotherapy (30 Gray in split course). Partial response was observed in 10 patients, and minimal response in 3. Thoracotomy disclosed unresectability in 3 patients. Fifteen complete resections consisted in 1 lobectomy and 14 pneumonectomies. There were no operative deaths (30 days). Postoperative recovery was uneventful in 3 patients with exploratory thoracotomy and in 1 patient with lobectomy. Following pneumonectomy, we observed 2 bronchopleural fistulae and 1 empyema. On pathology, 10 patients were stage IIIa, and 3 were stage I, whereas no residual tumor was found in 2 patients. During follow-up, local recurrence occurred in 2, and metastases in 8. On December 31st, 1993, 3 patients were alive at 44, 52, and 62 months respectively. Nine patients had died from cancer, and 3 from unrelated causes. Estimated survival was 66.7% at 1 year, 33.3% at 3 years, and 20% at 5 years. We conclude that induction therapy allowed satisfactory resection for marginally resectable tumors. Operative morbidity was increased in this group. However, the 5-year survival was similar to resectable stage IIIa cancer. |
| Databáze: | OpenAIRE |
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