| Autor: |
Simon, McCluney, Nilukshi, Wijesuriya, Vinayata, Sheshappanavar, Joanne, Chin-Aleong, Roger, Feakins, Robert, Hutchins, Ajit, Abraham, Satyajit, Bhattacharya, Roberto, Valente, Hemant, Kocher |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
ANZ journal of surgery. 88(9) |
| ISSN: |
1445-2197 |
| Popis: |
We report on our experience of the surgical management and outcomes of 11 patients with solid pseudopapillary tumour of the pancreas (SPT). We sought to correlate the immunohistochemical staining of these tumours with that previously reported in the literature.A retrospective analysis of the clinical presentation, radiological findings, surgical treatment, histopathological characteristics and outcomes for patients surgically managed with SPT at The Royal London Hospital. A literature search was performed to analyse the immunohistochemical stains commonly used to diagnose SPT.Between August 2006 and April 2016, 10 females and one male patient underwent surgery for SPT. The localization of the tumour was in the pancreatic head in two patients, one in the neck, three in the body and five in the tail. All 11 patients had localised disease. Six patients suffered post-surgical complications. Histopathology shows immunoreactivity for: β-catenin, vimentin, CD-10, CD-56, α1-antitrypsin and negative staining for synaptophysin and chromogranin. At a median of 24 months of follow-up, the disease-free survival rate was 100% and no recurrence was noted. A literature review generated 38 suitable articles with 116 individual cases of SPT, with high expression of vimentin and neuron specific enolase throughout, and low rates of chromogranin and synatophysin positivity.SPT is rare and affects mostly young women. An accurate diagnosis is important as the relative indolent behaviour can be managed with surgical resection even when large in size, bringing excellent long-term outcomes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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