Prognostic importance of coincidental coronary artery calcification on FDG-PET/CT oncology studies
| Autor: | Huda El, Mais, Robert, Kay, Hassan, Almubarak, Jennifer M, Rowe, Alyssa L S, Chow, Terrence, Ruddy, Rob S, Beanlands, Andrew M, Crean, Benjamin J W, Chow, Eugene C Y, Leung, Gary R, Small |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Incidental Findings Time Factors Coronary Artery Disease Middle Aged Prognosis Risk Assessment Fluorodeoxyglucose F18 Predictive Value of Tests Risk Factors Neoplasms Positron Emission Tomography Computed Tomography Prevalence Humans Female Radiopharmaceuticals Vascular Calcification Aged Retrospective Studies |
| Zdroj: | The international journal of cardiovascular imaging. 37(4) |
| ISSN: | 1875-8312 |
| Popis: | Coronary artery calcification (CAC) on body CT imaging is considered a coincidental finding in cancer patients. In order to determine the significance of CAC in cancer patients we evaluated the prognostic utility of CAC detected on oncology FDG-PET/CT studies. A retrospective study was performed of consecutive FDG-PET/CT studies from January to March 2011. CAC was identified on the CT portion of FDG/PET-CT studies. Chart review documented statin use, the Framingham risk score (FRS) (includes age, diabetes, hypertension, dyslipidemia and smoking), the primary malignancy and metastases. The primary end point was a composite of death and cardiovascular (CV) events (non-fatal myocardial infarction (MI), PCI or coronary artery bypass surgery (CABG)). 266 patients had a median follow up of 41 months (95% CI 31-56 months). CAC was noted in 140 patients. Based on CAC, potentially 84 patients would have had a change in statin prescribing (p 0.01). CAC was associated with the primary end point on univariable and multivariable analysis (OR 2.6 (95% CI 1.42-4.77) (p 0.01). On univariable Kaplan-Meier survival analysis, CAC was associated with decreased survival only in the absence of metastases (p 0.01). Cox proportional hazard modelling demonstrated CAC was associated with mortality and cardiac events in patients without metastases, whereas FRS was not (For CAC: HR 1.69 (95% CI 1.22-2.35), p = 0.002). CAC is commonly detected with oncology FDG-PET/CT. In cancer patients CAC was associated with an increased risk of clinical events. CAC reduced survival free time in patients without metastases. CAC might therefore be considered more than a coincidentaloma in patients without metastases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink