Glycation of Lys-16 and Arg-5 in amyloid-β and the presence of Cu

Autor:	Sebastian M, Fica-Contreras, Sydney O, Shuster, Nathaniel D, Durfee, Gregory J K, Bowe, Nathaniel J, Henning, Staci A, Hill, Geoffrey D, Vrla, David R, Stillman, Kelly M, Suralik, Roger K, Sandwick, Sunhee, Choi
Rok vydání:	2017
Předmět:	Models Molecular Amyloid beta-Peptides Glycosylation Protein Conformation Lysine Guanosine Monophosphate Cytochromes c Deoxyguanine Nucleotides Arginine Oxidative Stress Alzheimer Disease Amino Acid Sequence Oxidation-Reduction Copper DNA Damage
Zdroj:	Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 22(8)
ISSN:	1432-1327
Popis:	Extensive research has linked the amyloid-beta (Aβ) peptide to neurological dysfunction in Alzheimer's disease (AD). Insoluble Aβ plaques in the AD patient brain contain high concentrations of advanced glycation end-products (AGEs) as well as transition metal ions. This research elucidated the roles of Aβ, sugars, and Cu
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::16a4f17207165179ae18f545adc0b0a9 https://pubmed.ncbi.nlm.nih.gov/29038915 Zobrazit plný text záznamu Plný text ve formátu PDF