Carbamazepine differentially affects the pharmacokinetics of fexofenadine enantiomers

Autor:	Yumiko, Akamine, Masatomo, Miura, Norio, Yasui-Furukori, Midori, Kojima, Tsukasa, Uno
Rok vydání:	2011
Předmět:	Adult Male Short Report Stereoisomerism Young Adult Carbamazepine Asian People Area Under Curve Anti-Allergic Agents Humans Anticonvulsants Drug Interactions ATP Binding Cassette Transporter Subfamily B Member 1 Terfenadine
Zdroj:	British journal of clinical pharmacology. 73(3)
ISSN:	1365-2125
Popis:	This aim of this study was to characterize the impact of the P-glycoprotein (P-gp) inducer, carbamazepine, on fexofenadine enantiomer pharmacokinetics.Twelve healthy volunteers initially received a 60mg dose of fexofenadine alone. Subsequently, a 100mg dose of carbamazepine was administered three times daily (300mg day(-1) ), and on day 7, fexofenadine was co-administered.Carbamazepine significantly decreased the area under the plasma concentration-time curve and the amount excreted into the urine of (S)- and (R)-fexofenadine. The P-gp inducer showed a greater effect on the pharmacokinetic parameters of (S)-fexofenadine.This study indicates that carbamazepine may alter the pharmacokinetics of fexofenadine enantiomers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::16a16231adfe0489fdd7db0927f7c786 https://pubmed.ncbi.nlm.nih.gov/21950458 Zobrazit plný text záznamu Plný text