| Autor: |
Lina, Carvalho, Luís Eugénio, Fernandes, Filipe, Ferreira, Filipa, Januário, Diogo, Robles, Inês, Sanches, Edgar, Vaz, Manuel, Antunes |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Revista portuguesa de pneumologia. 16(1) |
| ISSN: |
2172-6825 |
| Popis: |
Primary neuroendocrine tumours (carcinoid tumours) account for about 4% of anterior mediastinal tumours concerning thymus localization. They appear to have a male predilection (3:1 ratio) and occur mostly between 40 and 60 years of age. Classified primarily as thymomas, they have been considered a different group of thymic neoplasia since 1972. They can be biologically active, mostly associated with MEN -1 (19 -25% of patients and more aggressive in these cases). As a locally invasive disease, with recurrence and metastasis in a high percentage of cases, it correlates with a poor prognosis. Staging is the most important determinant of survival. Encapsulated tumours diagnosed in early stages have an excellent prognosis, while locally invasive tumours in more advanced stages have a relatively poor prognosis as happens with thymomas. Complete surgical removal is the critical factor for long -term survival rates and the basis for treatment of all thymic tumours, independent of histologic type. As an important cause of death, especially in carcinoid tumours associated with MEN -1 and Cushing's syndrome, some authors advocate the need for profilactic thymectomy in these patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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