| Autor: |
Tatsuro, Kawamura, Yushi, Futamura, Erchang, Shang, Makoto, Muroi, Petra, Janning, Masayoshi, Ueno, Julian, Wilke, Shigeki, Takeda, Yasumitsu, Kondoh, Slava, Ziegler, Nobumoto, Watanabe, Herbert, Waldmann, Hiroyuki, Osada |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Bioscience, biotechnology, and biochemistry. 84(12) |
| ISSN: |
1347-6947 |
| Popis: |
Discovery of small-molecule inducers of unique phenotypic changes combined with subsequent target identification often provides new insights into cellular functions. Here, we applied integrated profiling based on cellular morphological and proteomic changes to compound screening. We identified an indane derivative, NPD9055, which is mechanistically distinct from reference compounds with known modes of action. Employing a chemical proteomics approach, we then showed that NPD9055 binds subunits of heterotrimeric G-protein G |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
