CD86 +1057GA polymorphism and susceptibility to acute kidney allograft rejection
| Autor: | Henda, Krichen, Imen, Sfar, Rafika, Bardi, Taieb, Ben Abdallah, Salwa, Jendoubi-Ayed, Walid, Ben Aleya, Mouna, Makhlouf, Thouraya, Ben Rhomdhane, Houda, Aouadi, Ezzeddine, Abderrahim, Khaled, Ayed, Yousr, Gorgi |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Graft Rejection Male Immunity Cellular Polymorphism Genetic Time Factors Tunisia Genotype Incidence T-Lymphocytes DNA Lymphocyte Activation Kidney Transplantation Polymerase Chain Reaction Acute Disease Humans Kidney Failure Chronic Transplantation Homologous Female Genetic Predisposition to Disease B7-2 Antigen Follow-Up Studies Retrospective Studies |
| Zdroj: | Iranian journal of kidney diseases. 5(3) |
| ISSN: | 1735-8604 |
| Popis: | CD86 is a costimulatory molecule that participates in the regulation of T-cell lymphocytes activation. Thus, we examined a genetic marker on the CD86 gene in kidney transplant outcome.In our retrospective study, 168 kidney allograft recipients were genotyped by direct sequencing. Patients were classified into 2 groups of 29 human leukocyte antigen (HLA)-identical haplotype allograft recipients and 139 recipients showing one or more mismatches in the HLA haplotype. Forty-five patients (26.8%) developed at least 1 acute rejection (AR) episode, 7 in the first and 38 in the second group.Acute rejection was associated with the presence anti-HLA antibodies before transplantation (P = .03). The AA genotype and A allele at position +1057 in the CD86 gene were more frequent in patients without AR (9.75% and 28.5%, respectively) compared with those showing an AR (2.22% and 23.3%, respectively). This difference was statistically significant in the anti-HLA-positive recipients, as AA frequency was 31.3% in non-AR patients and zero in AR ones (P = .04) and A allele frequency was 46.9% and 20.8%, respectively (P = .04). Patients bearing AA genotype reached a higher graft survival time (9.84 years) than those carrying GA (8.21 years, P = .32) or GG (7.61 years, P = .72) genotypes.These results suggest that AA genotype and A allele of CD86 +1057GA polymorphism may confer a protection against acute kidney allograft rejection in Tunisian patients. |
| Databáze: | OpenAIRE |
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