Relationship between anaemia management at haemodialysis initiation and patient prognosis

Autor:	Hiroshi, Kataoka, Ken, Tsuchiya, Toshiaki, Naganuma, Masayuki, Okazaki, Mizuki, Komatsu, Tomonori, Kimura, Shunji, Shiohira, Hiroshi, Kawaguchi, Kosaku, Nitta
Rok vydání:	2015
Předmět:	Male Iron Anemia Cerebral Infarction Prognosis Hemoglobins Cardiovascular Diseases Renal Dialysis Risk Factors Hematinics Humans Female Renal Insufficiency Chronic Aged Retrospective Studies
Zdroj:	Nephrology (Carlton, Vic.). 20
ISSN:	1440-1797
Popis:	It has been suggested that anaemia management during a transition period to haemodialysis could influence prognosis. In this paper, we have conducted a retrospective investigation on how Hb levels at haemodialysis initiation in patients with chronic kidney disease (CKD) influence the risk of cerebral infarction and cardiovascular events.Seventy-two patients who underwent initial haemodialysis between May 2012 and April 2014 were designated as subjects of the study and the patients were divided into a cohort with Hb levels ≥8 g/dL and a cohort with8 g/dL at haemodialysis initiation. The occurrence of cardiovascular events was analyzed using the Kaplan-Meier method and Cox proportional hazards model.The cohort with8 g/dL Hb levels at haemodialysis initiation demonstrated a tendency toward low dosage of ESA or iron preparation in the pre-haemodialysis (maintenance) phase. Significant incidence of cardiovascular (log rank, P = 0.002) and cerebrovascular (log rank, P = 0.02) events was observed. The results of multivariate analysis of the Cox proportional hazards model indicated that anaemia with8 g/dL Hb levels at haemodialysis initiation was a significant risk factor for coronary artery (hazard ratio = 12.85, P = 0.003) and cerebrovascular (hazard ratio = 5.11, P = 0.04) diseases post-haemodialysis.The results of this investigation indicate the possible involvement of low Hb levels at haemodialysis initiation as a factor in cardio- and cerebrovascular events. There, our results suggested that the administration of adequate dosage of iron preparations and ESA in the pre-haemodialysis period could help prevent cardio- and cerebrovascular events.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::164bbbb761789e0c45255fd77ffb2b39 https://pubmed.ncbi.nlm.nih.gov/26456159 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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