Monoclonal Epstein-Barr virus-related lymphoproliferative disorder following adult acute lymphoblastic leukaemia

Autor:	J M, Foran, S E, Slater, A J, Norton, S J, Wilkes, I J, Hart, A Z, Rohatiner
Rok vydání:	1999
Předmět:	Adult Gene Rearrangement Male Herpesvirus 4 Human Tumor Virus Infections Antineoplastic Combined Chemotherapy Protocols Humans Herpesviridae Infections Precursor Cell Lymphoblastic Leukemia-Lymphoma Polymerase Chain Reaction Lymphoproliferative Disorders
Zdroj:	British journal of haematology. 106(3)
ISSN:	0007-1048
Popis:	A 31-year-old patient in remission of acute lymphoblastic leukaemia (ALL), receiving oral maintenance chemotherapy (6-mercaptopurine, methotrexate (MTX), cyclophosphamide), developed a monoclonal, Epstein-Barr virus (EBV)-related lymphoproliferative disorder (LPD). Treatment consisted of excisional biopsy and the discontinuation of maintenance chemotherapy. To our knowledge, this is the first such report in an adult. The histological similarity to previous reports of 'lymphomatoid granulomatosis' following paediatric ALL suggests that they are the same disease. MTX may play a central role in the development of LPD in this setting. Although it is a rare complication of ALL, EBV-related LPD should be considered in patients who develop lymphadenopathy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::16404f5b08b47be96592a06a1f1443dd https://pubmed.ncbi.nlm.nih.gov/10468862 Zobrazit plný text záznamu Plný text