A single administration of interleukin-1 or amphetamine induces long-lasting increases in evoked noradrenaline release in the hypothalamus and sensitization of ACTH and corticosterone responses in rats

Autor:	E D, Schmidt, A N, Schoffelmeer, T J, De Vries, G, Wardeh, G, Dogterom, J G, Bol, R, Binnekade, F J, Tilders
Rok vydání:	2001
Předmět:	Male Hypothalamo-Hypophyseal System Time Factors Corticotropin-Releasing Hormone Drug Resistance Hypothalamus Median Eminence Rats Arginine Vasopressin Amphetamine Norepinephrine Adrenocorticotropic Hormone Exploratory Behavior Animals Central Nervous System Stimulants Rats Wistar Corticosterone Stress Psychological Interleukin-1
Zdroj:	The European journal of neuroscience. 13(10)
ISSN:	0953-816X
Popis:	Single administration of the cytokine interleukin-1beta (IL-1) or the psychostimulant amphetamine causes long-term sensitization of the hypothalamus pituitary adrenal (HPA) axis, i.e. enhanced adrenocorticotropine hormone (ACTH) and corticosterone responses weeks later. HPA responses to these stimuli involve activation of hypothalamic corticotropin-releasing hormone (CRH) neurons by noradrenergic projections to the paraventricular nucleus (PVN). In search of the underlying mechanisms, we studied the temporal pattern of HPA sensitization in relation to (1) the reactivity of noradrenergic projections to the PVN and (2) altered secretagogue production in hypothalamic CRH neurons. Single exposure to IL-1 or amphetamine induced cross-sensitization of ACTH and corticosterone responses 11 and 22 days later, but not after 42 days. Amphetamine-induced HPA sensitization was not accompanied by increased costorage of arginine vasopressin (AVP) in CRH terminals, as found previously after IL-1 pretreatment. The reactivity of noradrenergic terminals was assessed by measuring the electrically evoked release of [3H]-noradrenaline from superfused PVN slices. Single administration of amphetamine and IL-1 induced a long-lasting (up to 22 days) increase (up to 165%) of evoked noradrenaline release. This indicates that single exposure to psychostimulants or to cytokines can induce a long-lasting increase in stimulus-secretion coupling in brainstem noradrenergic neurons that innervate the PVN. This common, long-lasting functional change may underlie, at least in part, IL-1- and amphetamine-induced HPA cross-sensitization. In addition, increased AVP signalling by hypothalamic CRH neurons appears to play a role in IL-1-induced, but not in amphetamine-induced, HPA sensitization.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::16181a8b775711e51c55baaf415f8d83 https://pubmed.ncbi.nlm.nih.gov/11403685 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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