| Autor: |
G N, Soboleva, E A, Erpylova, G V, Riabykina, A V, Sobolev, E Sh, Kozhemiakina, V I, Fedorova, S Iu, Gorel'tseva, Iu A, Karpov |
| Rok vydání: |
2006 |
| Předmět: |
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| Zdroj: |
Terapevticheskii arkhiv. 78(3) |
| ISSN: |
0040-3660 |
| Popis: |
To study heart rate variability (HRV) according to 24-h Holter monitoring of ECG in patients with ischemic heart disease (IHD) and to examine effects of tianeptine on HRV.Twenty eight patients with IHD (17 males and 11 females aged 40-70 years) with a verified IHD diagnosis and atherosclerosis of the coronary arteries participated in the trial. Severity of depressive syndrome was assessed by CES-D questionnaire. HR V was assessed by weighted mean variation of the rhythmogram (WMVR) for 24 hours.Initial WMVR (m +/- sigma) in the study group (IHD with depression, n = 15) was 670 +/- 260 ms, in the control group (IHD without depression, n = 13) - 625 +/- 191 ms (the difference was insignificant (p = 0.72). Initial (m +/- sigma) WMVR in men of the study group (n = 6) before therapy was 460 +/- 139 ms that was less than in the control group (633 +/- 183 ms, n = 11).In men HRV depends on duration of the disease. There was a negative correlation between WMVR difference before and after treatment with tianeptine and difference of relevant depression indices with high correlation coefficient (-0.74, p = 0.03). |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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