| Autor: |
Ming-Zhen, Yang, Yan-Hui, Yuan, De-Pei, Wu, Wei-Rong, Chang, Jun, He, Wen-Ying, Di |
| Rok vydání: |
2007 |
| Předmět: |
|
| Zdroj: |
Zhonghua nei ke za zhi. 46(6) |
| ISSN: |
0578-1426 |
| Popis: |
To investigate the effects and prognosis of malignant hematological disease after HLA haploidentical hematopoietic stem cell transplantation (H-HSCT) without T-cell depletion.The clinical data of 31 cases with malignant hemopoietic disease treated with H-HSCT from July 2002 to July 2006 were analyzed, including 11 cases of standard risk and 20 of high risk.30 patients achieved engraftment of a median of 13 and 22 days for neutrophil and platelet, with an accumulative incidence of II - IV grade acute graft-versus-host disease (GVHD) 61.3%, and an accumulative incidence of chronic GVHD 41.9%. 13 patients survived with Karnofsky scale over 90.0% after a median follow-up of 24 months. 33 months of accumulative survival was 62.3% in the standard risk group and 35.0% in the high risk group. The CD(3)(+) T cells count of the graft and the disparity of HLA-A, B, DR loci were the major factors of impact on acute GVHD.HLA H-HSCT is an effective therapeutic method for malignant hematological disease, CD(3)(+) T cells count of the graft and the disparity of HLA-A, B, DR loci are the major factors of impact on acute GVHD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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