Protein tyrosine phosphatase 1B inhibitors for the treatment of type 2 diabetes and obesity: recent advances

Autor:	Elizabeth A, Harley, Nigel, Levens
Rok vydání:	2003
Předmět:	Mice Knockout Protein Tyrosine Phosphatase Non-Receptor Type 1 Oligonucleotides Antisense Substrate Specificity Mice Animals Humans Hypoglycemic Agents Insulin Anti-Obesity Agents Obesity Enzyme Inhibitors Protein Tyrosine Phosphatases Signal Transduction
Zdroj:	Current opinion in investigational drugs (London, England : 2000). 4(10)
ISSN:	1472-4472
Popis:	This review outlines the physiology of protein tyrosine phosphatase 1B (PTP1B) and its potential involvement in the states of insulin resistance that characterizes both obesity and type 2 diabetes. The primary focus of this review is upon the elucidation of the role and control of PTP1B enzyme activity in obesity and type 2 diabetes. Furthermore, since selectivity and cell permeability are the two most important requirements for the development of successful PTP1B inhibitors, recent progress in finding compounds meeting these criteria are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::15cfeeb946ab131148e5604e143232cf https://pubmed.ncbi.nlm.nih.gov/14649209 Zobrazit plný text záznamu