| Autor: |
T M, Williams, J, Wu, S, Bassinger, D, Feldman, S, Birkos, J, Kearns, M, Kamoun |
| Rok vydání: |
2002 |
| Předmět: |
|
| Zdroj: |
Tissue antigens. 60(2) |
| ISSN: |
0001-2815 |
| Popis: |
Nucleic acid-based methods for allele identification have revealed more than 470 polymorphic variants at the HLA-B locus. Screening of potential bone marrow donors with sequence specific primer polymerase chain reactions and sequence specific oligonucleotide probe hybridization assays revealed apparent variants within the B*58, *44, *15, and *48 allele groups. DNA sequencing of cloned DNA identified the new alleles B*5804, B*4418, and B*1558 within these groups and observed new sequence information for the previously reported allele B*4805. These findings further extend our knowledge of the substantial genetic variation present at the HLA-B locus within human populations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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