Heterotopic ossification following traumatic brain injury and spinal cord injury: insight into the etiology and pathophysiology

Autor:	V I, Sakellariou, E, Grigoriou, A F, Mavrogenis, P N, Soucacos, P J, Papagelopoulos
Rok vydání:	2012
Předmět:	Brain Injuries Ossification Heterotopic Animals Humans Bone and Bones Spinal Cord Injuries
Zdroj:	Journal of musculoskeletalneuronal interactions. 12(4)
ISSN:	1108-7161
Popis:	Neurogenic heterotopic ossification (HO) is the ectopic formation of lamellar bone in non-osseous tissues following traumatic brain or spinal cord injury. The associated complications affect greatly their quality of life. This fact has shifted the focus of scientific effort towards the investigation and understanding of related risk factors and the pathophysiological mechanisms. Recent advancements include the investigation for genetic predisposition and association various biomarkers. In the present article we will analyze the current concepts on this topic, based on clinical and physiological evidence and we will discuss the potential areas for future research on this field.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::155dd92dd1e69ee6060ab31c9e08d051 https://pubmed.ncbi.nlm.nih.gov/23196266 Zobrazit plný text záznamu