A natural anticancer pigment,Pheophytin a,from a seagrass acts as a high affinity human mitochondrial translocator protein (TSPO) ligand, in silico, to reduce mitochondrial membrane Potential (∆ψ
| Autor: | V L, Shailaja, V S, Christina, C D, Mohanapriya, P, Sneha, R, Lakshmi Sundaram, R, Magesh, C, George Priya Doss, K Mary Elizabeth, Gnanambal |
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| Rok vydání: | 2018 |
| Předmět: |
Membrane Potential
Mitochondrial Alismatales Cell Cycle Pheophytins Apoptosis Ligands Antineoplastic Agents Phytogenic Gene Expression Regulation Neoplastic Molecular Docking Simulation Receptors GABA A549 Cells Cell Movement Chlorocebus aethiops Animals Humans Computer Simulation Drug Screening Assays Antitumor Vero Cells |
| Zdroj: | Phytomedicine : international journal of phytotherapy and phytopharmacology. 61 |
| ISSN: | 1618-095X |
| Popis: | The present investigation looks at the most likely possibilities of usage of a naturally occurring photosynthetic pigment, Pheophytin a, from the seagrass, Syringodium isoetifolium, for plausible use as human TSPO ligand.Pheophytin a isolated in our laboratory previously was administered to A549 cell lines in vitro to examine its effects on cell migrations, DNA, cell cycle, Mitochondrial Membrane Potential and gene expressions. In silico tools were used to predict the nature of the compound and target binding.Pheophytin a hadICHence Pheophytin a could be seen as a possible TSPO ligand for targeting metastatic alveolar cancers like A549 via intrinsic apoptotic pathway.Given the inherent non-toxic nature of the compound and easy extractability from almost all autotrophic eukaryotes, one could be confident to testing in animal models. |
| Databáze: | OpenAIRE |
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