Prognostic value of captopril renal scintigraphy in renovascular hypertension
| Autor: | M, Dondi, S, Fanti, A, De Fabritiis, A, Zuccala, R, Gaggi, M, Mirelli, A, Stella, M, Marengo, F, Losinno, N, Monetti |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Captopril Blood Pressure Middle Aged Prognosis Renal Artery Obstruction Sensitivity and Specificity Renal Circulation Technetium Tc 99m Mertiatide Hypertension Renovascular Treatment Outcome Predictive Value of Tests Humans Technetium Tc 99m Pentetate Female Radioisotope Renography Angioplasty Balloon Aged |
| Zdroj: | Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 33(11) |
| ISSN: | 0161-5505 |
| Popis: | This study evaluates the prognostic value of captopril renal scintigraphy in hypertensive patients undergoing renal artery revascularization. Preoperative studies of 51 patients were correlated with blood pressure results at 6- and 12-mo follow-up. Captopril-renal scintigraphy was carried out 1 hr after oral administration of 50 mg of captopril, using either 220 MBq of 99mTc-DTPA or 74 MBq of 99mTc-MAG3, followed by a baseline study in case of abnormal results. Evidence of amelioration or normalization in relation to captopril study was considered predictive of blood pressure control following treatment. Blood pressure response was favorable in 37 patients, but failed to show any improvement in 14. The scintigraphic test was positive in 33 patients (15 cured, 17 improved, 1 failed) and negative in 18 (3 cured, 2 improved, 13 failed). Sensitivity and specificity for renovascular hypertension was 86.5% and 93%, respectively. For blood pressure cure and improvement, the test had positive and negative predictive values of 97% and 72%, respectively. A positive preoperative captopril renal scintigraphic result is a strong predictor of hypertension curability by renal artery revascularization. |
| Databáze: | OpenAIRE |
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