Effectiveness of a six-drug regimen (APO) without local irradiation for treatment of mediastinal lymphoblastic lymphoma in children

Autor:	B M, Camitta, S J, Lauer, J T, Casper, P A, Kirchner, L E, Kun, H W, Oechler, S E, Adair
Rok vydání:	1985
Předmět:	Male Adolescent Mercaptopurine Lymphoma Non-Hodgkin Mediastinal Neoplasms Methotrexate Doxorubicin Vincristine Child Preschool Antineoplastic Combined Chemotherapy Protocols Asparaginase Humans Prednisone Female Child
Zdroj:	Cancer. 56(4)
ISSN:	0008-543X
Popis:	Fourteen children with mediastinal lymphoblastic lymphoma (MLL) were treated with the six-drug APO protocol. This regimen includes aggressive intermittent chemotherapy and prophylactic central nervous system therapy. Mediastinal irradiation was given only for emergency relief of mediastinal compression (two children) or for incomplete resolution of mediastinal widening with chemotherapy (one child). All 14 patients achieved complete remission; only 1 has relapsed. Toxicities were not severe. APO is effective therapy for children with MLL. APO should receive further trials in children and adults with T-cell lymphoblastic lymphomas.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::14ff629efa0534ac2372de4cd4dcc2df https://pubmed.ncbi.nlm.nih.gov/3839432 Zobrazit plný text záznamu Plný text